Endocrine Abstracts

Purpose: Papillary thyroid cancer (PTC) is the most common thyroid and endocrine malignancy worldwide. Vitamin D (calciferol or 25-hydroxyvitamin D) (25(OH)D) has been postulated as a key modulator in several cancer-related pathways, although its contribution to PTC still remain controversial. The aim of the study was to analyse the correlation between 25(OH)D serum levels and 25(OH)D insufficiency as well as the risk of development of PTC and its variants: classical type (CV-...

Purpose: Papillary thyroid cancer (PTC) accounts for approximately 80% of all thyroid cancers and is defined by its unique cytologic and histologic features. Mutations of the RET and BRAF/V600 genes are found in nearly 70% of PTC cases. They are able to trigger the activation of mitogen-activated protein kinase pathways and to promote neoplastic cell proliferation. Genetic events may further lead to numerous different cell variants of PTC which may be identified via t...

Introduction: Neuroendocrine tumors (NETs) comprise a unique heterogeneous group of malignant growths that range from benign and multi-focal to highly malignant and metastatic. They are characterized by well-differentiated morphologic features and the ability to secrete neuropeptides, resulting in characteristic clinical syndromes. However, they are often diagnosed from the metastases of an unknown primary tumor. Therefore, high-quality genetic and immunohistochemical markers ...